Freshly Built CB450 engine.

Well I did a half assed quick fix and rough adjustment on the float with some nail polish and eyeballing the fuel level in the bowl and the bike runs about 90% better. No coughing and sputtering in town but WOT still misses but not nearly as bad. I think a new float and a good adjustment and some new sparkplugs should get the old girl running top notch again. Up to about 3/4 throttle is smooth and flawless its just when you dump the throttle wide open. it misses just a tad i'm going to guess its because of the additional weight of the nail polish all over the float and the roughed in halfway close fuel level set.

Sounds like you're on the right track.

Runs like a dream now thanks a lot everyone for pointing me in the right direction. Now If I could just figure out how to richen up the mid range just a tad for those long rides on hot days.

Try going a size up on the small jet.