I've been riding enduros a good portion of my riding career (about 25 years) and I always go for aggressive tires because in Ohio you never know what slop you will come across off road. I don't like getting stuck. I've found while riding to places like PA and WV I can do twisties at 55-60mph with aggressive dirt tires. I don't have the balls that some of the other guys in my group do but they can really lean into a corner on them. It's something you want to get used to, and the more square the profile of the tire the less predictable they will be... someone else mentioned it before as well. Rounded profiles are better if you're going to be leaning quite a bit. you will be surprised at how well knobbies grip on a DRY CLEAN road. On gravel roads they are downright fun, grab well and slide predictably. Its when the roads get wet that things get... ahem... interesting. Let me make that
dangerous. Braking distances also need to be increased. My rear tire will lock pretty easily., I've skidded into the middle of intersections when a light changed late.
This is what I run on my enduro (which happen to be almost the same size tire you are looking at)
Dunlop D606 in rear
and an intermediate terrain tire in the front (varies on what I have available)
The worst part about running knobbies on the street is that they cup really bad and really quick. I have to take my front tire off the rim and flip it about every 500-750 miles to get it to wear evenly. The rear will go a little longer, about 1000. You'll have to inspect them to see when they start to visibly cup, then flip it. Also make sure you do not get a directional pattern tire, or you can't flip it.
The nice thing is that there are tires that work well. I get about 5000-6000 miles out of my Dunlop rear on my XR250L, and that's running it dirt and street. The larger the blocks the longer it will last.
Let us know what you decide.