As far as mounting, you have a couple options. You can weld some type of flange to the frame that the tank will sit on and fab up a strap like the old dunstall racers used. Or you can glass in mounting points on the tank itself. Either way, it's no small job. One thing I can say for sure is that you'll want to use some kind of foam rubber or similar material between the tank and frame to reduce vibration and make sure said vibration doesn't allow the frame tor rub through the glass. In short, you don't want the tank to actually contact anything metal directly.
As far as fuel lines, just route them so they aren't touching the engine and you'll be fine. You can also use a heavy wall automotive style line for added piece of mind if you want.