If you're interested in upping your economy and dropping your revs, as well as increasing theoretical top speed, nothing like a gear change. Add a tooth or two to the front and knock three or four off the back. Less neck-snapping acceleration, but having power in a better place is great at highway speed if you've got an emergency and need to pass.
Unfortunately the timing stuff is trickier to do on fours(well, easier, but more expensive) than on two-strokes, which you can do with a metal file and a dry paintbrush if you're clever enough and know exactly what to do, and in the right place, stretching or changing the ports in a two (equivalent to changing the cam in a four) can improve your mileage and economy, though while your bike might make an extra 4 horsepower and get an extra 20mpg, it will not do the two at the same time.
Optimize *your* mileage with a half-fairing, a good aerodynamic helmet, a full-tuck riding style whenever you're cruising at speed, keeping your tires inflated to their maximum pressure, keeping everything oiled and tensioned just right, and maybe a gear change.
I've got a dorky little DT250B that I love to death, but at 21hp, it should do better than 48mpg. I'll be swapping some stuff around this coming week.