I know shit about airflow, does that help
Old Brit bikes used single carbs on twins and twin carbs on thr more sporty models but that didn't make a huge difference. So it looks like that will work BUT a Brit twin is 360 degree and that means each time the pistons go down only 1 cylinder is breathing in. So they alternate left and right and everything is fine.
On an inline 4 the two outer and inner pairs are like that, so if 1-4 and 2-3 were connected that way all would be fine, but that's not practical. If we connect 1-2 and 3-4 there's a period where intake pulses tend to get in each others way. Obviously then a 1-2 3-4 won't work as well, but the real question is does it work well enough for the street?
The answer seems to be that with larger carbs, jetted by someone that knows that particular bike and has access to a dyno and exhaust gas analysis they can work well enough. Wrong jets and it could be a PIA to get right.
And that brings us to the obvious question of WHY? Stock carbs with stock airboxes work fine. Some stock slide carbs work OK with individual filters. Stock CV carbs and pods are not a good answer in most situations.
And CR carbs are awesome but not cheap and not necessary for most of us.
And for the record, I go drag racing on my 2 stroke with CV carbs and pods which we all know cannot work, but it does. So to get back to your question - what bike and what's your thinking? It's best to define the problem before you chase the solution that may or may not be a good fit.