Plan the functions you want for your harness and understand what each wire is doing. Until you understand the purpose each wire serves and how it accomplishes that goal, it's unlikely you'll come out with a working harness at the end of things. After that, do your layout so you ensure that your measurements will all work out (measure twice, cut once). From that point, you should be able to wrap most of the wires in heat shrink or harness tape. Connectors go on last. Test each connection with a multimeter to ensure current will be flowing without too much resistance. Under an ohm is usually OK, but you should be able to get around half an ohm with properly stripped and crimped connections. Also test to ensure that NONE of your power wires have continuity to ground or you will blow fuses or cook wiring as soon as you plug it in.
Expect to spend about $30 on the wire you'll need (unless you're going with a very simple harness), $90 for the connection kit from Vintage Connections (one of my very best investments), and another $30 on misc parts like heat shrink, solder, harness wrap, etc. Double these prices if you're buying from an auto store instead of online.