could work... from what I understand, the cb450 pistons are 180' on the crank, so 90' on the cam, and with intake valve overlap, I would assume that there would be a point where both intake valves are open and could possibly spike the manifold vacuum level leading to a rich or lean condition... possibly... I'm not 100%
I think most bikes with single carb conversions have pistons at 360 on the crank, and 180' on the cam, so you would never be drawing air into both cylinders at the same time