Rule of thumb for a two stroke is 6.5 pounds of gas per HP hour at its most efficient.
But the issue with alcohol (and there are many) is getting enough flow. We used #400-500 main jets with Methanol compared to lower than 200 on gas and the pump and fuel tap and float valve all need to be upsized as do all the jets.
Methanol has a lower heating value of 56,562 BTU/pound compared to 114,761 for gas, so right there needs a flow increase of roughly 2:1 just to get the same heat energy, but that's not the real concern.
Let's tackle that from the other end. Let's say our motor makes 60 crank HP and burns 6.5 pounds of fuel at say 14.7:1. That means it's sucking it roughly 390 pounds of fuel and 5733 pounds of air.
That amount of air at an Air: fuel ration of 6.45 would burn 888 pounds of methanol and at say 4:1, would burn 1,433 pounds of methanol which is closer to 4 times as much methanol as gasoline.
Those calculations are just to get our brains into gear here.
So we know it will need a lot more fuel. Going back to stoichiometric numbers for a moment, Methanol uses 2.3 times as much methanol than gasoline. and 2.3 times as much fuel adds roughly 13% more heat energy.
The real reasons to use methanol is that it can withstand much higher compression than most gasoline except perhaps Q16 which is over 116 octane. And that's where the extra power comes from on a boosted 4 stroke. increase compression, pour in more fuel and see the HP numbers rise.
What also happens is that methanol has a higher latent heat of vaporization which is the energy required to change it from liquid state to gaseous state. It means that a methanol burning motor has colder denser air and that means more oxygen which may be one reason that it like to be richer than stoich. Because more oxygen molecules need more fuel compared to gas, so extra fuel and extra oxygen all help to make more power.
Except that all the fuel still only burns on the surface of the droplets so we need to atomize the fuel into smaller droplets and our old style carbs don't do a great job at that, so we end up with raw fuel going down the pipe, so the pipe is cold and no longer the tuned length.
Time to fit fuel injection and programmable ignition and to pre-book time at the local mental health facility.
It's all doable but takes time and effort to get it right. I am often reminded that the 1320 times on my bike are a function of the ability, or lack thereof, of the rider and that's me. In an 1/8th mile, launch technique is more important than the last extra HP and pipe temperature is probably more of an issue than we might expect.
Keep having fun and keep us informed.